Provider Details

Mark A. O'Rourke, MD

Mark O'Rourke
Request Appointment Online
Accepting New Patients
Patients Seen by Physician Referral Only
Provider Practice
GHS Cancer Institute
Oncology - Medical / Hematology
Area of Expertise
Cancer Care Delivery Research
Clinical Areas
Medical School
University Of California/Los Angeles
Duke University Medical Center
Residency Training
Internal Medicine
Duke University Medical Center
Fellowship Training
Geriatric Medicine (Int. Med)
UMG-GHS Employed
Programs & Procedures
Survivorship MDC;MDC Medical Oncologists;Center for Integrative Oncology
Board Certifications
Internal Medicine-American Board Of Internal Medicine
Medical Oncology-American Board Of Internal Medicine
Medical Oncology-American Board Of Internal Medicine
Dr. O’Rourke is a medical oncology cancer specialist with Cancer Centers of the Carolinas and the Medical Director for the GHS Center for Integrative Oncology and Survivorship. He grew up in Santa Barbara, California. He went to Stanford University for undergraduate and served in the U.S. Navy as an instructor at the Naval Nuclear Power School. He went to UCLA for medical school and to the Duke University Medical Center for residency training and fellowships in medical oncology and geriatrics. He has been a member of the medical staff at GHS since 1990. His practice includes blood and cancer illnesses that affect adults. He also participates in the GHS Gastrointestinal Cancer Multidisciplinary Clinic, which specializes in cancers of the stomach, pancreas, bile ducts, liver, and colon. The Center for Integrative Oncology and Survivorship is a separate clinic, which helps cancer survivors regain their full physical, mental, emotional, and spiritual health after cancer treatment. Integrative Oncology addresses the full range of a person’s experience with cancer, including exercise, nutrition, mind-body therapies, social support, and mental and spiritual health. Dr. O’Rourke has had a particular interest in medical ethics and serves on the ethics committees of the South Carolina Medical Association and the American Society of Clinical Oncology. He has taken additional training and become board certified in palliative care, which is a new specialty that addresses symptom control, pain relief, communication, and coordination of care for seriously ill persons. He also sees patients in the GHS Oncology Palliative Care clinic that provides this kind of care for oncology patients. Dr. O’Rourke and his wife, Rita, have two children and two grandchildren. In his free time, he helps Rita in the garden and in the kitchen.
Academic Appointments
Clinical Assistant Professor


GHS Cancer Institute
65 International Dr
Greenville, SC 29615
Accepting New Patients
(864) 987-7000
GHS Cancer Institute
900 W. Faris Road
Greenville, SC 29605
Accepting New Patients
(864) 404-2010
Practice Website

Physician Referral Required

This provider can be seen by physician referral only. If you do not have a referral from your Primary Care physician, we will be happy to assist you in obtaining the needed referral.